Alpha-1-Globulins Unit Converter

Alpha-1-globulins are a group of proteins identified as a distinct band on serum protein electrophoresis (SPEP). They typically represent about 3-5% of total serum proteins, with normal values ranging from 0.2-0.4 g/dL.

The alpha-1 fraction consists primarily of alpha-1-antitrypsin (AAT), which accounts for approximately 90% of the band intensity. Other proteins in this fraction include alpha-1-acid glycoprotein (orosomucoid), transcortin (corticosteroid-binding globulin), thyroid-binding globulin, and alpha-1-lipoprotein (HDL).

These proteins are classified as acute-phase reactants, meaning their levels increase during inflammation, infection, or tissue injury as part of the body's protective response.

Alpha-1-globulins are primarily synthesized by hepatocytes in the liver. Smaller amounts of alpha-1-antitrypsin are also produced by monocytes, macrophages, lung alveolar cells, and intestinal epithelial cells.